Transgender people (whose gender identity differs to their sex assigned at birth) may choose to undergo hormone therapy to align their physical appearance with their gender identity.
For a trans woman (born as a male and identifies as a female) medical transition includes oestrogen therapy. However, there have been concerns about an increased risk of cardiovascular events in trans women who have had oestrogen therapy.
A large study in the US, published in Annals of Internal Medicine, compared the incidence of cardiovascular events in more than 2800 trans women who were treated with oestrogen therapy with matched male and female controls (reference groups).
The results indicate a long-term increased risk of cardiovascular illnesses in trans women receiving oestrogen therapy compared to the reference group, highlighting a need for vigilance among health professionals who care for trans women.