Honey has a long history as human food and medicine, with possible beneficial effects for men’s sexual and reproductive health[1] but there is not a substantial evidence base for its ability to enhance male sexual performance. This hasn’t stopped some from creating honey-based products claiming to naturally improve male virility.

The US Food and Drug Administration (FDA) recently added another one of these honey products to its growing list of tainted sexual enhancement products. There are now 19 honey products among 384 entries in the database, which “includes only a small fraction of the potentially dangerous products marketed to consumers online and in stores”. All the listed honey products contain the phosphodiesterase type-5 (PDE5) inhibitors taladafil, sildenafil or both.


Why are men turning to supplements for sexual health?

The use of dietary supplements like honey to maintain wellness or treat health problems is motivated by several factors[2]:

  • The appeal of ‘natural substances’ over ‘chemicals’
  • Increased concern about wellness, and maintaining fitness and quality of life
  • The cost of conventional medicines
  • Distrust of pharmaceutical companies
  • A willingness to ‘try anything’ that ‘works’
  • Perceived value of tradition
  • Acceptability of supplements generally recognised as safe
  • Marketing of supplements.

At least one-third of Australian men use dietary supplements, and usage becomes more likely with advancing age[3] (mirroring the increasing incidence of sexual dysfunction as men get older[4]). Supplement use is increasing in Australia, as in other Western countries, and the number of listed dietary supplements grows by about 1,800 new items each year.


The state of supplements

Regulation of dietary supplement manufacturing in most jurisdictions is lax, leading to poor quality products that may present health risks2. For example, adulteration is present in 27% of herbal products sold globally, with the proportion of adulterated products highest in Australia (79%)[5]. More than half of a sample of traditional Chinese medicines available in Australia were contaminated by animal products (including leopard, viper, frog, cow, goat, sheep, rat, cat and dog), pharmaceuticals (including analgesics, anticoagulants, antihistamines, anti-inflammatories, stimulants, an antibiotic and a PDE5 inhibitor), poisons (brucine, strychnine) and heavy metals (including arsenic, lead and cadmium)[6].

The health risks of common contaminants of ‘natural’ therapies and supplements will be greater for some people than others. Interactions with prescribed medications are an obvious concern, as is the inherent toxicity of contaminants. Some people may substitute effective conventional medications for unproven natural therapies, effectively endangering themselves2.


What to ask your patients

Erectile dysfunction is a health problem that causes embarrassment or shame for some people, leading to denial or avoidance of seeking help[7] even though they know they need it[8]. There is an obvious appeal of online access to assistance for erectile dysfunction but a risk that comorbidities of the condition, like cardiovascular disease or depression, are missed[9].

The contamination of an ostensibly safe and natural product such as honey, with PDE5 inhibitors, presents the possibility of dangerous interactions with nitrates or in people with a variety of cardiovascular problems.

The Australian Therapeutic Goods Administration’s product safety alert list details several unregistered products containing PDE5 inhibitors. However, it does not appear to list the honey products on the US FDA list, despite local availability of the same products from an online retailer based in NSW.

Low-risk complementary medicines can be listed on the Australian Register of Therapeutic Goods without evaluation by the TGA, and only a fraction (there are more than 12,000 of them) are subjected to post-market compliance reviews[10]. Some products may be considered foods and regulated by Food Standards Australia New Zealand2 (there is no mention of contaminated honey products on the FSANZ recall list[11]).

It’s impossible for health professionals to keep on top of all the dietary supplements and other complementary medicines that their patients might be using. However, the likelihood of a patient taking a dietary supplement, natural remedy or other complementary medicine is high and these products may not always be what they claim to be. Educating patients about their use of alternative medicines and dietary supplements is necessary for their protection and enquiring about their use is important to ensure appropriate care.

A/Prof Tim Moss
A/Prof Tim Moss

Associate Professor Tim Moss has PhD in physiology and more than 20 years’ experience as a biomedical research scientist. Tim stepped away from his successful academic career at the end of 2019, to apply his skills in turning complicated scientific and medical knowledge into information that all people can use to improve their health and wellbeing. Tim has written for and Scientific American’s Observations blog, which is far more interesting than his authorship of over 150 academic publications. He has studied science communication at the Alan Alda Centre for Communicating Science in New York, and at the Department of Biological Engineering Communication Lab at MIT in Boston.


[1] Zaid et al., 2021. Protective Roles of Honey in Reproductive Health: A Review. Molecules

[2] Binns et al., 2018. Problems and prospects: public health regulation of dietary supplements. Annual Review of Public Health

[3] Burnett et al., 2017. Dietary Supplement Use among Australian Adults: Findings from the 2011–2012 National Nutrition and Physical Activity Survey. Nutrients

[4] Weber et al., 2013. Risk factors for erectile dysfunction in a cohort of 108 477 Australian men. Medical Journal of Australia

[5] Ichim, 2019. The DNA-based authentication of commercial herbal products reveals their globally widespread adulteration. Frontiers in pharmacology

[6] Coghlan et al., 2015. Combined DNA, toxicological and heavy metal analyses provides an auditing toolkit to improve pharmacovigilance of traditional Chinese medicine (TCM). Scientific Reports

[7] Yafi et al., 2016. Erectile dysfunction. Nature Reviews Disease Primers

[8] De Boer et al., 2005. The prevalence of bother, acceptance, and need for help in men with erectile dysfunction. Journal of Sexual Medicine

[9] Hsiang et al., 2020. Evaluation of online telehealth platforms for treatment of erectile dysfunction. Journal of Urology



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